The Drosophila CAKI / CMG protein , a homolog of human CASK , is essential for regulation of neurotransmitter vesicle release
نویسندگان
چکیده
Authors Mauro A. Zordan, Michele Massironi, Maria Giovanna Ducato, Geertruy te Kronnie, Rodolfo Costa, Carlo Reggiani, Carine Chagneau, Jean-René Martin and Aram Megighian. Department of Human Anatomy and Physiology, University of Padova, 35131 Padova, Italy Department of Biology, University of Padova, 35131 Padova, Italy Equipe ATIPE : Bases Neurales du Mouvement chez la Drosophile, NAMC, CNRS, UMR-8620, Université Paris Sud, Orsay, France
منابع مشابه
Drosophila CAKI/CMG protein, a homolog of human CASK, is essential for regulation of neurotransmitter vesicle release.
Vertebrate CASK is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. CASK is present in the nervous system where it binds to neurexin, a transmembrane protein localized in the presynaptic membrane. The Drosophila homologue of CASK is CAKI or CAMGUK. CAKI is expressed in the nervous system of larvae and adult flies. In adult flies, the expression of caki is particu...
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CaMKII is critical for structural and functional plasticity. Here we show that Camguk (Cmg), the Drosophila homolog of CASK/Lin-2, associates in an ATP-regulated manner with CaMKII to catalyze formation of a pool of calcium-insensitive CaMKII. In the presence of Ca(2+)/CaM, CaMKII complexed to Cmg can autophosphorylate at T287 and become constitutively active. In the absence of Ca(2+)/CaM, ATP ...
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